Mehran Alavi - Department of biological science, Faculty of Science, Kurdistan University, Kurdistan, Sanandaj, Iran
Michael Hamblin - Laser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein, ۲۰۲۸, South Africa
M. Mozafari - Australasian Nanoscience and Nanotechnology Initiative (ANNI), ۸۰۵۴ Monash University LPO, Clayton, Victoria ۳۱۶۸, Australia
Irwin Rose Alencar de Menezes - Laboratory of Pharmacology and Molecular Chemistry; Department of Biological Chemistry; Regional University of Cariri; Rua Coronel Antônio Luis ۱۱۶۱, Pimenta, CEP ۶۳۱۰۵-۰۰۰, Crato, Ceará, Brazil
Henrique Douglas Melo Coutinho - Laboratory of Microbiology and Molecular Biology; Department of Biological Chemistry; Regional University of Cariri; Rua Coronel Antônio Luis ۱۱۶۱, Pimenta, CEP ۶۳۱۰۵-۰۰۰, Crato, Ceará, Brazil

Bacterial infections can be caused by contamination of labile blood products with specific bacteria, such as Staphylococcus aureus and Staphylococcus epidermidis. Hospital equipment, bio-protective equipment, delivery systems, and medical devices can be easily contaminated by microorganisms. Multidrug-resistant bacteria can survive on various organic or inorganic polymeric materials for more than ۹۰ days. Inhibiting the growth and eradicating these microorganisms is vital in blood transfusion processes. Blood bags and other related medical devices can be improved by the incorporation of organic or inorganic nanomaterials, particularly silicon dioxide (SiO۲) nanoparticles. The addition of solid organic or inorganic nanoparticles to synthetic polymers or biopolymers can provide new properties in addition to antimicrobial activity. Among these NPs, formulations composed of SiO۲ nanoparticles and polymers have been shown to improve the mechanical and antimicrobial properties of catheters, prosthetic inserts, blood bags, and other medical devices SiO۲ nanoparticles possess several advantages, including large-scale synthetic availability, simple one-pot synthesis methods, porous structure for loading antibacterial agents, good biocompatibility, and thermal stability. Plasticized polyvinyl chloride is the main polymer, which has been functionalized by these nanoparticles. In this review, we discuss the recent advances and challenges regarding the functionalization of polyvinyl chloride by SiO۲ nanoparticles to hinder bacterial contaminations in blood products.  

Bacterial Contamination, labile blood products, plasticized polyvinyl chloride, blood bags, inorganic nanomaterials, bactericidal activity