M. Ionov - Department of General Biophysics, University of Lodz, Banacha ۱۲/۱۶, ۹۰-۲۳۷, Lodz, Poland.
D. Wróbel - Department of General Biophysics, University of Lodz, Banacha ۱۲/۱۶, ۹۰-۲۳۷, Lodz, Poland.
K. Gardikis - Department of Pharmaceutical Technology, School of Pharmacy University of Athens, Panepistimiopolis, Zografou ۱۵۷۷۱, Athens, Greece.
S. Hatziantoniou - Department of Pharmaceutical Technology, School of Pharmacy University of Athens, Panepistimiopolis, Zografou ۱۵۷۷۱, Athens, Greece.
C. Demetzos - Pharmaceutical Technology, School of Pharmacy University of Athens, Panepistimiopolis, Zografou ۱۵۷۷۱, Athens, Greece.
J. P. Majoral - Laboratorie de Chimie de Coordination, CNRS, UPR ۸۲۴۱ ۲۰۵, route de Narbonne ۳۱۰۷۷, Toulouse, France.
B. Klajnert - Department of General Biophysics, University of Lodz, Banacha ۱۲/۱۶, ۹۰-۲۳۷, Lodz, Poland.
M. Bryszewska - Department of General Biophysics, University of Lodz, Banacha ۱۲/۱۶, ۹۰-۲۳۷, Lodz, Poland.

Large unilamellar liposomes and multilamellar vesicles consisting of DMPC interacted with cationic phosphorus-containing dendrimers CPDs G۳ and G۴. DSC and ζ -potential measurements have shown that liposomal-dendrimeric molecular recognition occurs due to the interaction between the complementary surface groups. Calorimetric studies indicate that the enthalpy of the transition of the lipids that interact with CPDs is dependent on the dendrimers generation. These results can be used in order to rationally design mixed modulatory liposomal locked-in dendrimeric, drug delivery nano systems.

Dendrimer, Lipid membrane, Dendrimer/membrane interaction