Maziar Kaveh Baghbadorani - Department of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Jaleel Mehrzad - Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Mahdi Vodjgani - Department of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Alireza Khosravi - Department of Mycology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
Vahid Akbarinejad - Department of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran

 BACKGROUND: The incidence of diseases among dairy cows is high in the postpartum period, which reduces dairy enterprise and higher demands for antibiotics. Considering this, the notion of promoting heath and reducing antibiotic application in dairy cow medicine by taking advantages of bioactive phytochemicals in herbal extracts is emerging. OBJECTIVES: This study's main purpose was to investigate the effects of supplementing Holstein dairy cows' ration in the close-up period by Immunofin® polyherbal aqueous extract on the normal physiology, clinical health, and hematological and biochemical parameters of postpartum dairy cows. METHODS: In this experiment, the herbal extract was supplemented in a close-up period diet for cows in the treatment group (n=۱۰). However, cows in the control group (n=۱۰) received precisely the same ratio as the placebo. The clinical health of cows was assessed, and some of their biochemical and hematological parameters were com-pared between the two groups. RESULTS: Cows in the treatment group had a lower incidence of retained fetal membrane and metritis (P=۰.۰۱). In addition, cows in the treatment group had a lower concentration of serum nonesterified fatty acid (P<۰.۰۰۱), and a lower number of peripheral blood leukocytes and lymphocytes count among cows in the treatment group (P<۰.۰۰۰۱). In contrast, their mean corpuscular hemoglobin and mean corpuscular volume were higher (P<۰.۰۰۰۱). CONCLUSIONS: In conclusion, Immunofin® supplementation in a close-up period had no negative impacts on prepartum cows' clinical health and could desirably alter some of the clinical, biochemical and hematological pa-rameters.

Clinical health, Immunofin, Metabolic status, Polyherbal extract, Transition period