Orthobiologics: Current role in Orthopedic Surgery and Traumatology

Orthobiologics are organic and synthetic materials that help in the cure of musculo-skeletal problems and are utilizedin Orthopaedic Surgery, both in and out of the surgical theater, to augment the possibilities of curing bone and softtissue lesions. Taking into account that their effect is frequently multifactorial and, in some occasions not entirely comprehended,together with the insufficient clinical information, orthobiologics should be scrupulously assessed againstother secure and clinically accepted options. The fundamental orthobiologics today ready for use in Orthopedic Surgeryare the following: osseous hollow fillers, extracellular matrix (ECM) substances, platelet-rich plasma (PRP), bonemorphogenetic protein-۲ (BMP-۲), bone marrow aspirate (BMA), bone marrow aspirate concentrate (BMAC), and mesenchymalstem cells (MSCs). It is predictable that in the time to come we will have more secure and more efficaciousorthobiologics. Meanwhile, it is paramount that orthopedic surgeons have appropriate information of contemporaryorthobiologics (biological adjuvants) so that they can utilize them correctly.Level of evidence: III

Keywords:

Bone void fillers , BMA , BMAC , BMP-۲ , ECM products , MSCs , Orthobiologics , PRP