ZnO-NPs as an efficient reusable heterogeneous catalyst for synthesis of ۱,۴-Dihydropyrimidine derivatives in solvent-free conditions

An efficient synthesis route to ۱,۴-dihydropyrimidine derivatives from reaction of divergent aldehydes with ethylacetoacetate and urea under solvent-free conditions by ZnO nanoparticles as a relative in expansive, eco-friendly, easy available, non-volatile, non-explosion, thermally robust, recyclable and easy to handle catalyst at ۹۰°C with excellent yields is described. Unenhanced reaction times, simple reaction protocol and work-up, have been improved synthesis of these materials in the presence of this heterogeneous catalyst.

Keywords:

۱ , ۴-Dihydropyrimidinones , ZnO Nanoparticles , Solvent-free conditions , Heterogeneous catalyst , H-NMR