Fe۳O۴@SiO۲-NH۲ as an efficient nanomagnetic carrier for controlled loading and release of acyclovir
Publish place: International Journal of Nano Dimension، Vol: 8، Issue: 4
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_IJND-8-4_010
تاریخ نمایه سازی: 24 تیر 1401
Abstract:
Considering many applications of functionalized metal oxide nanoparticles in magnetic resonance imaging, drug delivery, neutron irradiation, electronics, catalysis and optics; herein, a new strategy is developed to functionalize magnetite nanoparticles to improve their performances in the delivery of acyclovir. In this study, magnetite Fe۳O۴ nanoparticles are synthesized by hydrothermal method. Then, the surface hydroxyl groups were extended by treating with TEOS (tetraethyl orthosilicate); Finally, TMPA (trimethoxysilyl propylamine) was anchored to the surface hydroxyl groups to produce amino-functionalized Fe۳O۴@SiO۲-NH۲ magnetic nanoparticles. The synthesized sample was characterized by UV-Vis, FESEM, FT-IR, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of acyclovir as an active antiviral drug model involving amine and hydroxyl functional groups. For this purpose, the amount of loading/release of the drug was investigated in different pHs, including mouth and stomach pH values. The screened experimental parameters in this study revealed that the prepared magnetite nanoparticles decorated with amine functional groups are successful in the controlled delivery of acyclovir.
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Authors
Reza Tayebee
Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, ۹۶۱۷۹-۷۶۴۸۷, Iran.
Mojtaba Fattahi Abdizadeh
Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Mostafa Mohammadpour Amini
Department of Chemistry, Shahid Beheshti University, G. C., Tehran, ۱۹۸۳۹۶۳۱۱۳, Iran.
Nasrin Mollania
Department of Biology, School of Sciences, Hakim Sabzevari University, Sabzevar, Iran.
Zahra Jalili
Department of Chemistry, School of Sciences, Hakim Sabzevari University, Sabzevar, ۹۶۱۷۹-۷۶۴۸۷, Iran.
Hamed Akbarzadeh
Department of Biology, School of Sciences, Hakim Sabzevari University, Sabzevar, Iran.
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