The effect of consumption nettle extract and aerobic training on MMP۲ and FGF۲ gene expression in mice with melanoma

Introduction:Cancer is one of causes of death in the world that resulting  of abnormal cells growth  in the body. Aim:The aim of this study was to investigate the effect of nettle extract consumption and aerobic exercise on MMP۲ and FGF۲ gene expression in mice with melanoma. Method: ۲۰ male Wistar rats were randomly divided into ۴ groups including: control, aerobic, nettle and aerobic + nettle. The training program included running on a treadmill for ۳۰ minutes at a speed of ۱۶ meters per minute. One meter per minute was added every week until it reached ۲۲ meters per minute in the eighth week. The experimental group consumed ۳۰ mg / kg / day of nettle ethanol extract orally for ۸ weeks. RT PCR was used to measure the expression of MMP۲ and FGF۲ genes.   Findings: Data analysis showed that consumption of nettle extract and endurance training did not have a significant effect on MMP۲ and FGF۲ gene expression in different groups (p = ۰.۰۶۴, p = ۰.۴۰۵, respectively). Although a decrease in MMP۲ and FGF۲ gene expression was observed in nettle and hybrid groups; but it did not reach a significant level. Discussion& Conclusion: The results showed that nettle may reduce angiogenic activity and cancer prognostic factor in mice with melanoma.

Keywords:

Nettle extract , MMP۲ , FGF۲ , Melanoma cancer , عصاره گزنه , MMP۲ , FGF۲ , سرطان ملانوما.