Development and Evaluation of Nanomagnetic Carrier for the Controlled Loading and Release of Celecoxib

The aim of the present study was to develop synthesize, characterize, and find many applications of functionalized metal oxide nanoparticles. Herein, a new strategy is developed to functionalize magnetite nanoparticles to improve their performances of cerium oxide-functionalized Fe۳O۴@SiO۲@CeO۲ magnetic nanoparticles (FSC). In this study, after preparing optimized FSC, characterization and identification of their chemical structure were carried out by FT-IR, FESEM, VSM, TGA, DLS, and XRD. Afterward, the functionalized nanoparticles were examined in the delivery of celecoxib as an active drug model involving cerium oxide and hydroxyl functional groups. The results with respect to particle size, present investigation indicate that the formulations (mFSC=۵ mg, pH=۳.۳) can be considered as best among various formulations. Dynamic light scattering (DLS) techniques used to measure particle size and zeta potential distribution revealed successful preparation of an Fe۳O۴@SiO۲@CeO۲  nanocomposite prepared on Fe۳O۴@SiO۲ (FS), with a hydrodynamic size distribution of ۴۵ nm.

Keywords:

Dynamic Light Scattering (DLS) , Magnetite , nanocomposite , Celecoxib , TGA