Rapid and simple magnetic solid-phase extraction of bisphenol A from bottled water, baby bottle, and urine samples using green magnetic hydroxyapatite/β-cyclodextrin polymer nanocomposite

Bisphenol A (BPA) is a synthetic organic compound widely used as a starting material in plastics synthesis. The high toxicity of BPA has promoted the development of effective analytical methods for its separation and detection in complex samples. Herein, a novel magnetic nanocomposite consisting of hydroxyapatite and β-cyclodextrin polymer (MHAP/β-CDP) was designed and synthesized by a novel and convenient method for magnetic solid-phase extraction (MSPE) of BPA. The adsorption mechanisms of the MHAP/β-CDP toward BPA were mainly based on the hydrophilic interactions and formation of host-guest inclusion complex. The prepared magnetic nanocomposite was characterized by the vibrating-sample magnetometer (VSM), field emission scanning electron microscopy (FESEM), X-ray diffraction (XRD) analysis, and thermogravimetric analysis (TGA). To obtain the best extraction conditions, the extraction parameters were optimized. Under the optimized conditions, MSPE combined with high-performance liquid chromatography-diode array detector (HPLC-DAD) was applied for the determination of BPA in bottled water, baby bottle, and urine samples. The proposed method provided low limits of detection (۰.۰۶ ng mL-۱) and quantification (۰.۱۸ ng mL-۱), good linearity (R۲ = ۰.۹۹۶) in the range of ۰.۵-۱۰۰۰.۰ ng mL-۱, good repeatability (۳.۲-۴.۱%, n = ۴) and reproducibility (۴.۹-۵.۴%, n = ۳ days). Furthermore, satisfactory relative recoveries in the range of ۹۷.۰-۱۰۲.۰% were obtained for quantification of BPA in bottled water, baby bottle, and urine samples.

Keywords:

Bisphenol A , Hydroxyapatite , Magnetic solid-phase extraction , Nanocomposite , Urine , β-cyclodextrin polymer