Evaluation of Δ۹-tetrahydrocannabinol effect on autism inflammatory factors by molecular docking study
Publish Year: 1401
نوع سند: مقاله کنفرانسی
زبان: English
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شناسه ملی سند علمی:
WCMMPS07_020
تاریخ نمایه سازی: 24 مرداد 1401
Abstract:
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder and is characterised by social communication difficulties. Inflammation and immune system activation is reported as pathogenicity of ASD. It has been demonstrated that cannabis consumption improves interpersonal communication and reduces hostile feelings. In this study, we evaluated the beneficial effect of Δ۹-tetrahydrocannabinol (THC) on ASD’s inflammatory factors with bioinformatic tools. Molecular docking showed THC interact with ASD’s inflammatory factors specially IL۱۲B and RELA. It seems that THC alleviates inflammation in ASD by targeting ASD’s inflammatory factors.
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Authors
Javad Amini
Department of Medical Biotechnology and Molecular Science, North Khorasan University of Medical Science, Bojnurd, Iran
Zahra Sepehri Roushan
Department of Biology Science, University of Calgary, Calgary, Canada
Omid Mohammadalizadeh
Department of Agronomy and Plant Breeding, Agricultural and Natural Resources College, University of Tehran, Karaj, Iran
Bahram Bibak
Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran; Research Center of Natural Products Safety and Medicinal Plants, North Khorasan University of Medical Sciences, Bojnurd, Iran