Carvacrol attenuated neuroinflammation, oxidative stress and depression and anxiety like behaviors in lipopolysaccharide-challenged rats

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_AJP-12-5_006

تاریخ نمایه سازی: 29 مرداد 1401

Abstract:

Objective: The beneficial effect of carvacrol on neuroinflammation, oxidative damage of brain tissue, and depressive- and anxiety-like behaviors after lipopolysaccharide (LPS) administration were evaluated in rats.Materials and Methods: Vehicle (۱% Tween ۸۰), ۱ mg/kg of LPS, and carvacrol (۲۵, ۵۰, or ۱۰۰ mg/kg administered prior to LPS) were injected and behavioral and biochemical tests were done.Results: The results of forced swim test revealed that carvacrol attenuated immobility time and increased activity and climbing times (p<۰.۰۵ to p<۰.۰۰۱). The results of elevated plus maze also revealed that treatment by carvacrol prolonged the open arms time and entries and decreased the time and entries in the closed arms (p<۰.۰۵ to p<۰.۰۱). Carvacrol enhanced crossing, time, and traveled distance in the central segment of the open field and increased total crossing and distance while attenuating the peripheral zone time (p<۰.۰۵ to p<۰.۰۰۱). All doses of carvacrol attenuated TNF- α (tumor necrosis factor α) and NO (nitric oxide) in the brain (p<۰.۰۱ to p<۰.۰۰۱). The ۵۰ and the ۱۰۰ mg/kg doses of carvacrol decreased malondialdehyde (p<۰.۰۰۱ for both), and the ۱۰۰ mg/kg dose of carvacrol increased the content of the thiol (p<۰.۰۰۱).Conclusion: In conclusion, carvacrol improved the behavioral consequences of LPS challenge and attenuated neuroinflammation and brain tissue oxidative stress in rats.

Authors

Hossein Salmani

Student Research Committee, Jiroft University of Medical Sciences, Jiroft, Iran

Zahra Hakimi

Faculty of Medicine, Ghalib University, Herat, Afghanistan

Zohre Arab

Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Narges Marefati

Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

Mohammad Reza Mahdinezhad

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Abolfazl RezaeiGolestan

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Farimah Beheshti

Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.

Mohammad Soukhtanloo

Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

AmirAli Mahnia

Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Mahmoud Hosseini

Psychiatry and Behavioral Sciences Research Center, Mashhad University of Medical Sciences, Mashhad, Iran