Introduction: Chronic vascular inflammatory state plays an important role in the pathophysiology of thalassemia. Cross-sectional studies suggest that exercise has anti-inflammatory effects, leading to lower levels of several proatherogenic inflammatory markers. However, this has yet to be confirmed by randomized prospective trials. The present pilot study examined the effect of Concurrent) Training on inflammatory markers of Beta Thalassemia Major
Patients.Methods: In this semi-experimental study, ۱۸ patients with Beta Thalassemia major were selected as convenient samples and voluntarily divided in two groups: experimental (n=۹) and control group (n=۹). The subjects of the experimental group attended the concurrent (Resistance-Endurance) Training for eight weeks (۳ Sessions per week and each sessions ۹۰ min). Subjects' blood samples were taken before and after training protocol in order to measurement hs-CRP, IL-۶, IL-۱ᵦ andIL-۱۲ Serum levels. The levels of these markers were measured by using an enzyme-linked Electro immune assay (ELISA) kits. For data analysis the Repeated measures ANOVA, was used. All statistical analysis was performed by SPSS software (V.۱۹). The level of significance was considered P<۰.۰۵.Results: The results indicated reduction of HS-CRP and IL-۶ after eight weeks of concurrent training compared to the control group (P<۰.۰۵), but IL-۱ᵦ and IL-۱۲ was increased in training group (P<۰.۰۵).Conclusion: The reduction of HS-CRP and IL-۶serum level and its natural range in the exercise protocol, can be a regulating response to inflammatory condition in patients under certain exercise conditions without any pathological importance and maybe improved chronic vascular inflammation. We demonstrated that concurrent (resistance-endurance) training is inversely correlated with levels of pro-inflammatory markers in Beta Thalassemia major patients, possibly retarding the process of atherosclerosis andresults showed that immune modulation.