Effect of Concurrent Training on inflammatory markers of Beta Thalassemia Major Patients

Publish Year: 1397
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_HMJ-22-1_002

تاریخ نمایه سازی: 30 مرداد 1401

Abstract:

Introduction: Chronic vascular inflammatory state plays an important role in the pathophysiology of thalassemia. Cross-sectional studies suggest that exercise has anti-inflammatory effects, leading to lower levels of several proatherogenic inflammatory markers. However, this has yet to be confirmed by randomized prospective trials. The present pilot study examined the effect of Concurrent) Training on inflammatory markers of Beta Thalassemia Major Patients.Methods: In this semi-experimental study, ۱۸ patients with Beta Thalassemia major were selected as convenient samples and voluntarily divided in two groups: experimental (n=۹) and control group (n=۹). The subjects of the experimental group attended the concurrent (Resistance-Endurance) Training for eight weeks (۳ Sessions per week and each sessions ۹۰ min). Subjects' blood samples were taken before and after training protocol in order to measurement hs-CRP, IL-۶, IL-۱ᵦ andIL-۱۲ Serum levels. The levels of these markers were measured by using an enzyme-linked Electro immune assay (ELISA) kits. For data analysis the Repeated measures ANOVA, was used. All statistical analysis was performed by SPSS software (V.۱۹). The level of significance was considered P<۰.۰۵.Results: The results indicated reduction of HS-CRP and IL-۶ after eight weeks of concurrent training compared to the control group (P<۰.۰۵), but IL-۱ᵦ and IL-۱۲ was increased in training group (P<۰.۰۵).Conclusion: The reduction of HS-CRP and IL-۶serum level and its natural range in the exercise protocol, can be a regulating response to inflammatory condition in patients under certain exercise conditions without any pathological importance and maybe improved chronic vascular inflammation. We demonstrated that concurrent (resistance-endurance) training is inversely correlated with levels of pro-inflammatory markers in Beta Thalassemia major patients, possibly retarding the process of atherosclerosis andresults showed that immune modulation.

Authors

Golnaz Arbab

Department of Sport Science, Kish International Campous, Tehran University, Kish Island, Iran

Seyed Alireza Sobhani

Department of Pathology, Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran

Mohammad Reza Kordi

Department of Sport Science, Tehran University, Tehran, Iran

Abbas Ali Gaeini

Department of Exercise Physiology, Tehran University, Tehran, Iran