Antimicrobial Potential of Titanium Dioxide Nanoparticles in Urinary Tract Infections: An Experimental Study on the Growth Inhibitory Activity and Biofilm Inhibition

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JCMI-8-4_001

تاریخ نمایه سازی: 30 مرداد 1401

Abstract:

Background: T Microorganisms cause many diseases for the human body such as urinary tract infection and,therefore, it is highly important to eliminate and control them. Bacterial resistance to different types of antibioticswas increased and it is necessary to find alternative agents to eliminate these microbes.Methods: This study aimed was to evaluate the antimicrobial effect of different concentrations of titaniumdioxide nanoparticles (TiO۲ NPs) on some gram-positive bactria, gram-negative bacteria, and Candida albicans.TiO۲ NPs were synthesized using the chemical methods, coated with carboxymethyl cellulose (CMC) andprepared in different concentrations (۰.۰۹۸, ۰.۱۹۶, ۰.۳۹۲, ۰.۷۸۴, ۱.۵۶۸, and ۳.۱۳۶ mg/mL). Eventually, aminimum inhibitory concentration (MIC) and a minimum biofilm inhibitory concentration (MBIC) were appliedto investigate the effect of TiO۲ NPs on microorganisms.Results: According to the study results, the MICs of TiO۲ NPs were found to be ۱.۴۸۹, ۱.۲۰۸, and ۱.۱۶۶ mg/mL for Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae as the Gram-negative bacteria,respectively; and they were discovered to be ۰.۵۱۲, ۰.۸۳۰, and ۰.۷۰۷ mg/mL for Streptococcus pneumoniae,Staphylococcus aureus, and Staphylococcus epidermidis as the Gram-positive bacteria, respectively. As for C.albicans, as the yeast strain, MIC was ۰.۲۵۳ mg/ mL. The MBIC of more than ۹۰% of TiO۲ NPs was ۶.۲۵ mg/mLfor both Gram-negative and Gram-positive bacterial types and ۱.۵۶۲ mg/mL for C. albicans.Conclusions: It was concluded that TiO۲ NPs were effective antimicrobial agents for Gram-positive bacteria,Gram-negative bacteria, and C. albicans, but their inhibitory effect on yeast was greater than that of bacteria.

Authors

Sabar Jabbar Shawkat

Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran

Khosrow Chehri

Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran