Mohammad Javad Dehghan Esmatabadi - Malek - Ashtar University of Technology, Tehran, Iran
Fatemeh Movahedi Motlagh - Cellular and Molecular Research Center, Faculty of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran- Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
Azadeh Etemadzadeh - Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran
Samira Hajigholami - Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran

The capability of cancer cells including tumor initiation, maintenance, and extension is associated with cancer stem cells. The substantialfeatures of CSCs are self - renewal and pluripotency. Therapeutic resistance of CSCs can result in cancer recurrence andfailure of cancer treatment. Isolation and characterization of CSCs are required for targeted cancer therapies. CSCs can be distinguishedand separated by surface markers. In this review, after definition of CSC hypothesis, different markers of CSC are introduced.The information about CSC markers provides promise for better isolation and more effective CSC-targeting therapeutic in future.

Cancer, Stem Cells, Markers