The relation between vitamin D status and anemia in patients with end stage renal disease on regular hemodialysis

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_JRE-7-1_015

تاریخ نمایه سازی: 30 مرداد 1401

Abstract:

Introduction: Anemia is a common complication in end-stage renal disease (ESRD) patients on regular hemodialysis (HD). There has been a lot of interest recently in the non-classical effects of ۲۵(OH) vitamin D (calcidiol), including its association with erythropoiesis and anemia pathogenesis.Objectives: To study the relation between anemia and vitamin D status in patients on regular HD.Patient and Methods: This study is a cross-sectional study that included ۹۰ patients on regular HD. Vitamin D status was classified into deficient (<۲۰ ng/mL), insufficient (۲۰-۳۰ ng/mL) and sufficient (>۳۰ ng/mL).Results: The level of vitamin D measured in the patients ranged between ۳.۵ to ۶۶ ng/mL with median of ۱۶.۳۵ ng/mL. There were statistically significant positive correlations between vitamin D levels and the level of hemoglobin (P < ۰.۰۰۱), serum calcium levels (P < ۰.۰۰۱) and serum PO۴ levels (P = ۰.۰۲۳). Higher hemoglobin levels were statistically related to both higher vitamin D values (P < ۰.۰۰۱) and higher serum calcium concentration (P < ۰.۰۰۱). Meanwhile, a significant negative correlation was found between hemoglobin levels and serum PTH values (P < ۰.۰۰۱).Conclusion: There was a significant association between the status of vitamin D and the level of hemoglobin in dialysis population who were studied, independent from iron status. other associations with hemoglobin levels included PTH level and calcium.

Authors

Essam Nour el Din Afifi

Department of Internal Medicine and Nephrology, Ain Shams University, Cairo, Egypt

Ahmed Mohamed Tawfik

Department of Internal Medicine and Nephrology, Ain Shams University, Cairo, Egypt

Essam Eldin Rashad Saeed Abdulkhalek

Cairo University, Cairo, Egypt

Lina Essam Khedr

Department of Internal Medicine and Nephrology, Ain Shams University, Cairo, Egypt