Kidney Complications of COVID-۱۹: A Systematic Review and Meta-Analysis

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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JR_JRHSU-21-1_003

تاریخ نمایه سازی: 30 مرداد 1401

Abstract:

Background: Some patients with coronavirus disease ۲۰۱۹ (COVID-۱۹) have been reported tohave developed mild to severe kidney injuries. The current systematic review and meta-analysiswas carried out to estimate the prevalence and incidence of acute kidney injury (AKI) amongCOVID-۱۹ patients.Study design: A systematic review and meta-analysisMethods: PubMed, Embase, Scopus, Web of Science, and MedRxiv databases were searchedfrom December ۱, ۲۰۱۹, up to July ۲۷, ۲۰۲۰. Two independent co-authors completed the screeningprocess, data extraction, and quality assessment of the retrieved records. Random-effects metaanalyseswere used to determine the pooled prevalence and ۹۵% confidence interval (CI) of AKIamong COVID-۱۹ patients.Results: Out of ۲,۳۳۲ unique identified records, ۵۱ studies were included in the review. Overall,the studies were carried out on ۲۵,۶۰۰ patients. A total of ۶,۵۰۵ patients (in ۱۸ cross-sectionalstudies) were included to estimate the pooled prevalence of AKI, and ۱۸,۹۳۴ patients (in ۲۷ cohortstudies) were included to determine the pooled incidence of AKI. The pooled prevalence of AKIwas estimated as ۱۰.۰۸% (۹۵% CI: ۴.۵۹, ۱۷.۳۲; I۲=۹۸.۵۶%; P<۰.۰۰۱). Furthermore, the pooledincidence of AKI was ۱۲.۷۸% (۹۵% CI: ۷.۳۸, ۱۹.۳۶; I۲=۹۹.۲۷%; P<۰.۰۰۱). The mean (۹۵% CI)values of serum creatinine (SCr), blood urea nitrogen (BUN), potassium, and sodium were ۷۶.۱۰(۶۹.۳۶, ۸۲.۸۴), ۴.۶۰ (۴.۰۴, ۵.۳۰), ۳.۹۴ (۳.۷۸, ۴.۱۱), and ۱۳۹.۳۰ (۱۳۸.۲۶, ۱۴۰.۳۶) mmol/L,respectively.Conclusions: The AKI is a considerable complication among COVID-۱۹ patients and should bescreened for on clinical examinations. The BUN, SCr, potassium, and sodium levels were withinthe normal ranges.

Authors

Naser Nasiri

MSc, Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

Shoboo Rahmati

Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran

Abbas Etminan

MD, Department of Internal Medicine, School of Medicine, Endocrinology and Metabolism Research Center, Afzalipour Hospital, Kerman University of Medical Sciences,Kerman, Iran

Hamid Sharifi

PhD, HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of MedicalSciences, Kerman, Iran

Azam Bazrafshan

MSc, HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of MedicalSciences, Kerman, Iran

Mohammad Karamouzian

MSc, HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran- School of Population and Public Health, Faculty of Medicine, Univer