The Effect of Venom of Egyptian Spitting Cobra Naja nubiae on Vascular Permeability of Hepatic and Renal Tissues
عنوان مقاله: The Effect of Venom of Egyptian Spitting Cobra Naja nubiae on Vascular Permeability of Hepatic and Renal Tissues
شناسه ملی مقاله: JR_MEBIO-9-1_003
منتشر شده در June در سال 1400
شناسه ملی مقاله: JR_MEBIO-9-1_003
منتشر شده در June در سال 1400
مشخصات نویسندگان مقاله:
Asmaa Saad Mahmoud Shokhba - Department of Zoology, Faculty of Science, Suez Canal University, ۴۱۵۲۲, Ismailia, Egypt
Mohamed A.Abdel-Rahman
Mohammed Alaa El-Deen A.Omran - Department of Zoology, Faculty of Science, Suez Canal University, ۴۱۵۲۲, Ismailia, Egypt
Nahla Soliman El-Shenawy - Department of Zoology, Faculty of Science, Suez Canal University, ۴۱۵۲۲, Ismailia, Egypt
خلاصه مقاله:
Asmaa Saad Mahmoud Shokhba - Department of Zoology, Faculty of Science, Suez Canal University, ۴۱۵۲۲, Ismailia, Egypt
Mohamed A.Abdel-Rahman
Mohammed Alaa El-Deen A.Omran - Department of Zoology, Faculty of Science, Suez Canal University, ۴۱۵۲۲, Ismailia, Egypt
Nahla Soliman El-Shenawy - Department of Zoology, Faculty of Science, Suez Canal University, ۴۱۵۲۲, Ismailia, Egypt
Background: Among venomous elapid snakes, cobras have the highest public awareness, as their venom
represents a combination of proteins, peptides, and enzymes that have a range of biochemical and
pharmacological roles and are also the main constitutes of biological activity and lethal toxicity.
Objectives: The study aimed to evaluate the effect of the venom of Egyptian Spitting Cobra, Naja nubiae,
on the vascular permeability based on the extravasation of the azo dye Evans blue (EB) into the tissues of
the liver and kidneys of animals envenomed with low (¼ LD۵۰; ۰.۳۲ mg/kg) and high (½ LD۵۰; ۰.۶۵ mg/
kg) doses at three sampling times (۳۰, ۱۲۰, ۳۶۰ min) post-injection of the venom.
Methods: Fifty-four adult male Albino rats (۸ weeks old and ۱۸۰±۲ ۰ g body weight) were divided
into three main groups (n=۶). In the control group, rats were subcutaneously (SC) injected with saline
solution. Envenomed groups were SC injected, one group with ۰.۳۲ mg/kg and the other group with ۰.۶۵
mg/kg body weight of crude venom, respectively. Rats were I.V injected with EB dye ۲۰ minutes before SC
injection with saline solution as control animals and with Naja nubiae venom as treatment groups.
Results: The results illustrated a high significant rate of EB extravasation to hepatic and renal tissues by
the colorimetric determination of EB dye concentration.
Conclusion: The venom of Naja nubiae can cause increased hepatic and renal vascular permeability
which may explain the inflammatory effect induced by this venom.
کلمات کلیدی: Naja nubiae, Snake, Venom, Vessel permeability, Evans blue
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1501812/