Standardized Extract of Costus Afer Ker. Gawl leaves Modulates Reproductive Toxicity Caused by Fructose- Streptozotocin Administration in Type-۲ Diabetic Rats Model
عنوان مقاله: Standardized Extract of Costus Afer Ker. Gawl leaves Modulates Reproductive Toxicity Caused by Fructose-
Streptozotocin Administration in Type-۲ Diabetic Rats Model
شناسه ملی مقاله: JR_MEBIO-9-2_005
منتشر شده در در سال 1400
شناسه ملی مقاله: JR_MEBIO-9-2_005
منتشر شده در در سال 1400
مشخصات نویسندگان مقاله:
Tope Gafar Atere - Department of Medical Biochemistry, College of Health Sciences, Osun State University, Osogbo, Nigeria
Oluseyi Adeboye Akinloye - Department of Biochemistry, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
Regina Ngozi Ugbaja - Department of Biochemistry, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
David Ajiboye Ojo - Department of Microbiology, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
خلاصه مقاله:
Tope Gafar Atere - Department of Medical Biochemistry, College of Health Sciences, Osun State University, Osogbo, Nigeria
Oluseyi Adeboye Akinloye - Department of Biochemistry, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
Regina Ngozi Ugbaja - Department of Biochemistry, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
David Ajiboye Ojo - Department of Microbiology, College of Bioscience, Federal University of Agriculture, Abeokuta, Nigeria
Background: Co-administration of streptozotocin and fructose is believed to induce type ۲ diabetes as
well as to cause reproductive toxicity and testicular damage via increasing oxidative stress in rats.
Objectives: In this study, the potential protective effect of Costus afer leaves methanol extract (CAME) on
andrological parameters and pituitary-gonadal axis hormones of type ۲ diabetes (T۲D) in rats treated with
streptozotocin and fructose was investigated.
Methods: A total of ۳۵ rats were divided into five groups, each including seven rats. Group ۱ received
normal saline, whereas T۲D was induced in rats from groups ۲, ۳, ۴, and ۵. Group ۲ served as diabetic
control; while groups ۳, ۴, and ۵ were treated orally with ۱۲ mg/kg body weight (BW) of metformin as
well as ۱۰۰ and ۲۰۰ BW of CAME, respectively, for ۴ weeks. Hypothalamic–pituitary–gonadal responses,
andrological parameters, DNA fragmentation, and oxidative stress parameters of the reproductive organs
were examined in all treatment groups.
Results: Administration of CAME reduced the degenerative changes in testes, epididymis and improved
pituitary-gonadal axis hormone concentrations, and sperm morphology occasioned by the treatments.
Conclusion: It was concluded that the administration of CAME ameliorated reproductive abnormalities in
T۲D rat models treated with streptozotocin-fructose administration.
کلمات کلیدی: Costus afer, Andrological parameters, Diabetes mellitus, Oxidative stress, Sperm analysis
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1501820/