Zeynab Akbari - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Assieh Jafari - Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mazhar Rostami-Nejad - Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sajjad Tavakkoli - Shahid Beheshti University of Medical Sciences, Tehran, Iran

Severe Acute Respiratory Syndrome Coronavirus ۲ (SARS-CoV-۲), a new member of the human coronavirus family that was declared a pandemic in March ۲۰۲۰ by the World Health Organization (WHO), has caused more of the ۴۰۰ million cases and ۵ million deaths worldwide. Vaccines are considered the main hope in stopping and ending the COVID-۱۹ epidemic. The success of vaccines depends largely on immunological memory. People at high risk for COVID-۱۹ re-infection show no evidence of B-cell memory. Also, ۲۰% of infected patients do not develop an antibody response. Clinical trials and cross-sectional studies have reported different results on the effect of exercise on vaccination performance. The aim of this review study is to show that exercise plays an important role in preventing re-infection and creating better protective responses after vaccination. The results showed that regular exercise training increased the response of secondary B cell memory antibodies and reduced the severity of re-infection and adverse effects of vaccines.

COVID-۱۹, Exercise Training, Vaccines, Re-infection