Mohammad Javaherian - PhD Candidate, Liver Transplantation Research Center, Imam Khomeini Hospital Complex AND Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
Narges Dabbaghipour - Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran
Zinat Mohammadpour - Liver Transplantation Research Center, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
Behrouz Attarbashi Moghadam - Associate Professor, Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran

BACKGROUND: The current study was aimed at updating prior systematic review and meta-analyses (SRMA‎) in order to determine the effects of supervised exercise-based cardiac rehabilitation (EBCR) and introduce a suitable exercise protocol for lipid profile changes in patients with cardiovascular disease (CVD).METHODS: PubMed, Scopus, and Web of Science databases were searched from ۱۹۸۰ to December ۲۰۱۸. All published, randomized controlled trials (RCTs) reporting the efficacy of supervised EBCR in patients with CVD and measuring at least ۱ component of lipid profile were included. The quality of articles was assessed based on the Physiotherapy Evidence Database (PEDro) scale. Random effect model was used to calculate the effect size of post-intervention data.RESULTS: Initially ۷۷۴ RCTs were reviewed, ۱۴ of them were included in the study. In comparison with the control group, supervised EBCR was associated with higher serum levels of high-density lipoprotein (HDL) [weight mean difference (WMD): ۱.۲۹۷; ۹۵% confidence interval (CI): -۱.۶۲۰, ۴.۲۱۴] and lower serum level of low-density lipoprotein (LDL) (WMD: -۷.۷۹۷; ۹۵%CI: -۱۴.۰۰۵, -۱.۵۸۸), total cholesterol (TC) (WMD: -۱۱.۰۲۹; ۹۵%CI: -۲۰.۷۱۶, -۱.۳۴۲), and triglyceride (TG) (WMD: -۱۴.۶۰۲; ۹۵%CI: -۲۸.۹۹۲, -۰.۲۱۲).CONCLUSION: It seems that EBCR is correlated with an insignificant increase in HDL serum level and a significant decrease in LDL, TC, and TG serum levels. Considering subgroup analysis results, it is suggested that long duration, moderate exercise volume (EV), and combination of aerobic exercise (AE) and resistance exercise (RE) be used to improve HDL and TG serum levels. Short duration, high EV, and AE+RE seem to significantly reduce LDL serum level. Moreover, moderate EV is associated with a significant reduction in TC level.

Cardiac Rehabilitation, Cardiovascular Diseases, Exercise, Lipids, Meta-Analysis