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Use of lipid-lowering medicinal herbs during pregnancy: A systematic review on safety and dosage

Publish place: ARYA Atherosclerosis، Vol: 13، Issue: 3
Publish Year: 1396
نوع سند: مقاله ژورنالی
زبان: English
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لینک ثابت به این Paper:
https://civilica.com/doc/1504752

شناسه ملی سند علمی:

JR_RYA-13-3_005

تاریخ نمایه سازی: 2 شهریور 1401

Abstract:

BACKGROUND: Hyperlipidemia is one of the important diseases in pregnancy that causes fetal abnormalities during pregnancy and after the birth. Unfortunately, the usual anti-fat drugs are associated with high morbidity in fetus and due to people's inclination towards taking herbs, it is required to identify side effects of medicinal herbs in pregnancy. The aim of this study was to present hypolipidemic herbs that would not any complications for mother and fetus. METHODS: In this review article, the major electronic databases such as EBSCO, Central Register of Controlled Trials (CENTRAL), China Network Knowledge Infrastructure (CNKI), Cochrane, Google scholar, MEDLINE, SciVerse, Scopus, and Web of Science were searched using the key words “herbal” and “hyperlipidemia”, “herbal” and “pregnancy” matched by MeSH from their respective inceptions till September, ۲۰۱۶. Total of ۱۷۲۳ publications (۱۴۵ review articles, ۸۵۵ original research articles, and ۷۲۳ abstracts) about the effect of herbals on hyperlipidemia and ۶۸۲ publications (۲۰۰ abstracts, ۴۲۳ original research articles, and ۵۹ review articles) about the effect of herbals in pregnancy were retrieved. At the end, a list of medicinal plants effective on hyperlipidemia alongside their effects on pregnancy was developed. Finally, the plants effective on hyperlipidemia and safe during pregnancy were determined and their dosage, complications, mechanism of action, and side effects were reported. RESULTS: A total of ۱۱۰ effective herbs on hyperlipidemia were identified and complications of ۹۵ plants in pregnancy were studied. At last, among the ۵۵ selected plants effective on hyperlipidemia and examined for pregnancy, we reported ۱۲ herbs with their dosage and special considerations that can be used to treat hyperlipidemia during pregnancy. CONCLUSION: Some medicinal plants can be used to treat hyperlipidemia during pregnancy without any significant side effects both on mother or fetus. 

Keywords:

Hyperlipidemias , Pregnancy Outcome , Fertility , Dyslipidemia , Herbals , Medicinal Plants , Oxidative Stress

Authors

Hojjat Rouhi-Boroujeni

PhD Candidate, Student Research Committee AND Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Esfandiar Heidarian

Professor, Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Hamid Rouhi-Boroujeni

Pulmonologist, Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Minasadat Khoddami

Pharmacist, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

Mojgan Gharipour

PhD Candidate, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Mahmoud Rafieian-Kopaei

Professor, Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran

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