The outbreak fingolimod cardiovascular side effects in relapsing-remitting multiple sclerosis patient: A longitudinal study in an Iranian population
Publish place: ARYA Atherosclerosis، Vol: 12، Issue: 6
Publish Year: 1395
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_RYA-12-6_004
تاریخ نمایه سازی: 2 شهریور 1401
Abstract:
BACKGROUND: Fingolimod (FTY-۷۲۰) has shown efficacy in relapsing multiple sclerosis (MS), while some side effects of this drug have been recognized that the most important is cardiovascular side effects. The aim of this study was to evaluate the cardiovascular side effects of FTY-۷۲۰. However, the effect of fingolimod on cardiac has not been well recognized. This study was designed to evaluate the cardiovascular side effects of fingolimod in relapsing-remitting multiple sclerosis (RRMS) patient in an Iranian population. METHODS: This prospective clinical trial study was performed on ۲۰۰ RRMS patients. The patients received a single daily oral dose of fingolimod ۰.۵ mg. During the first ۶ hours after the first fingolimod dose, the patients’ vital signs and electrocardiographic traces were continuously monitored. Moreover, the patients followed up over ۶ months after receiving fingolimod. RESULTS: The results showed that pulse rate (P < ۰.۰۰۱), systolic blood pressure (BP) (P < ۰.۰۰۱), and diastolic BP (P < ۰.۰۰۱) were decreased significantly during ۶ hours after receiving the first dose of fingolimod. The most reduction in vital sign was observed in ۳ hours. Arrhythmia, bradycardia, and dizziness were the other complications of fingolimod, which were detected in our study. CONCLUSION: All the side effects such as hypotension and bradycardia were happened in first ۳ hours after receiving the fingolimod. Indeed, we advise clinicians to monitor the patients for first ۶ hours after initiation of fingolimod to decrease worse side effects.
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Authors
Morteza Abdar
Professor, Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
Payam Ebrahimifar
Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Masoud Etemadifar
Professor, Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
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