ASSOCIATION BETWEEN DIETARY SALT INTAKE AND RESERVATION OF RENAL FUNCTION IN PATIENTS WITH MILD HYPERTENSION

BACKGROUND: It is now hypothesized whether restricted salt intake can be a potential precursor to renal dysfunction in mild hypertension state. We aimed to study the association between salt intake and renal function in patients with mild hypertension. METHODS: One hundred consecutive hypertensive Iranian patients (with systolic blood pressure ۱۴۰-۱۶۰ mmHg and/or diastolic ۹۰-۱۰۰ mmHg) who were referred to the hypertension research center, Isfahan, Iran, between ۲۰۱۱ and ۲۰۱۴ for screening of hypertension were assessed. Renal function was assessed by measuring serum creatinine (Cr) and creatinine clearance (CrCl). Daily salt intake was assessed on the basis of ۲۴ h urinary sodium excretion. RESULTS: There was no association between the amounts of sodium intake and serum Cr concentration (r = ۰.۱۳۸, P = ۰.۱۷۴), however, an association was revealed between sodium intake and value of CrCl (r = ۰.۳۰۳, P = ۰.۰۰۳). Multivariable linear regression model showed that sodium intake could effectively predict renal function assessed by CrCl (Beta = ۰.۰۷۰,P = ۰.۰۱۶). CONCLUSION: There is an association between sodium intake and reservation of renal function in mild hypertension state and thus by restriction of dietary salt intake, reserving renal function, and preventing appearance and progression of renal insufficiency in higher degrees of hypertension can be facilitated.  

Keywords:

Dietary , Salt Intake , Renal Function , Mild Hypertension