THE EFFECT OF PROBIOTIC SOY MILK AND SOY MILK ON ANTHROPOMETRIC MEASURES AND BLOOD PRESSURE IN PATIENTS WITH TYPE II DIABETES MELLITUS: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL

BACKGROUND: The objective of this clinical trial was to assess the effects of probiotic soy milk and soy milk on anthropometric measures and blood pressure (BP) in type ۲ diabetic (T۲D) patients. METHODS: A total of ۴۰ patients with T۲D, ۳۵-۶۸ years old, were assigned to two groups in this randomized, double-blind, controlled clinical trial. The patients in the intervention group consumed ۲۰۰ ml/day of probiotic soy milk containing Lactobacillus planetarium A۷ and those in control group consumed ۲۰۰ ml/day of soy milk for ۸ weeks. Anthropometric and BP measurements were performed according to standard protocols. For detecting within-group differences paired-sample t-tests was used and analysis of covariance was used for determining any differences between two groups. (The trial has been registered in the Iranian Registry of Clinical Trials, identifier: IRCT: IRCT۲۰۱۴۰۵۲۶۵۰۶۲N۸). RESULTS: In this study, we failed to find any significant changes between probiotic soy milk and soy milk in term of body mass index (۲۶.۶۵ ± ۰.۶۸ vs. ۲۶.۳۳ ± ۰.۷۴, P = ۰.۳۰۰) and waist to hip ratio (۱.۴۹ ± ۰.۰۸ vs. ۱.۵۴ ± ۰.۱, P = ۰.۱۷۰). Although soy milk did not have any effect on BP, probiotic soymilk significantly decreased systolic (۱۴.۷ ± ۰.۴۸ vs. ۱۳.۰۵ ± ۰.۱۶, P = ۰.۰۰۱) and diastolic BP (۱۰ ± ۰.۷ vs. ۹.۱ ± ۱, P = ۰.۰۳۱). CONCLUSION: In our study, probiotic soy milk in comparing with soy milk did not have any beneficial effects on anthropometric measures in these patients. We need more clinical trial for confirming the effect of probiotic foods on anthropometric measure in diabetic patients. However, probiotic soy milk decreased systolic and diastolic BP significantly.

Keywords:

Probiotics , Obesity , Diabetes Mellitus , Soy Milk , Blood Pressure