Maryam Taghdir - MS, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.
Abolghasem Djazayeri - PhD, Professor of Nutrition, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.
Mahmoud Djalali - PhD, Professor of Biochemistry, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.
Mohammadreza Eshraghian - PhD, Associate Professor, Department of Biostatistics, School of Health, Tehran University of Medical Sciences, Tehran.
Asadollah Rajab - MD, Endocrinologist, Iranian Diabetes Society, Tehran.
Haleh Sadrzade Yegane - MS, Instructor, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.
Mahkameh Ashourpour - MS, Department of Nutrition and Biochemistry, School of Health, Tehran University of Medical Sciences, Tehran.
Mojtaba Sepandi - MS, Instructor, Department of Epidemiology and Biostatistics, School of Health, Jondishapour University of Medical Sciences, Ahwaz.

Abstract    BACKGROUND: Leptin, the product of the ob gene, could have a role in the pathogenesis of obesity and non-insulin dependent diabetes mellitus (NIDDM). The aim of this study was to investigate relationships between serum leptin concentration and insulin, glucose, HbA۱c levels and insulin resistance in diabetic women.    METHODS: We studied ۴۵ diabetic women and ۴۵ healthy women (controls) who aged ۴۵-۶۰ years and had BMI of ۲۵-۳۰ kg/m۲. Serum leptin, insulin, HbA۱c, fasting blood sugar and insulin resistance were determined in the two groups.    RESULTS: There was a significant positive correlation between leptin and insulin (r = ۰.۲۹۵, P = ۰.۰۴۹) and insulin resistance (r = ۰.۳۲۹, P = ۰.۰۲۷) in controls but non-significant correlation between leptin and HbA۱c and fasting blood sugar were observed in the two groups.    CONCLUSION: This study did not document any significant relationship between serum leptin and insulin, glucose, HbA۱c and insulin resistance in diabetic women.      Keywords: Type ۲ Diabetes Mellitus, Leptin, Insulin.