Mohammad Masoomi - Associate Professor of Cardiology, Physiology Research Center, Shafa Hospital, Kerman University of Medical Sciences, Kerman.
Fatemeh Ghaemi - Resident of Internal Medicine, Physiology Research Center, Shafa Hospital, Kerman University of Medical Sciences, Kerman.
Aliakbar Haghdost - Assistant Professor in Epidemiology, Physiology Research Center, Shafa Hospital, Kerman University of Medical Sciences, Kerman.
Hamidreza Rashidinejad - Assistant Professor of Cardiology, Physiology Research Center, Shafa Hospital, Kerman University of Medical Sciences, Kerman.

Abstract    BACKGROUND: The aim of this study was to assess resolution of ST segment elevation after streptokinase therapy in opium-addict patients with acute myocardial infarction (AMI).    METHOD AND MATERIALS: The studied population consisted of AMI patients who have criteria for thrombolytic therapy. Three groups of ST segment resolution were defined: complete resolution (≥ ۷۰%), partial resolution (۷۰% to ۳۰%) and no resolution (< ۳۰%).    RESULTS: A total number of ۲۴۰ patients were studied (۱۲۶ opium addicts and ۱۱۴ non-addicts). Overall, ۵۲.۵% of addicts and ۳۸.۷% of non-addicts had complete ST segment resolution (P = ۰.۰۶). The odds of ST elevation resolution in addicts was ۱.۸ (۹۵%, CI: ۱.۰۹-۲.۹۵) compared to non-addicts. When it was adjusted for other variables, it reduced to ۱.۰۳ (۹۵%, CI: ۰.۵۴-۱.۹۷).     CONCLUSION: There was not any significant relationship between opium addiction and response to thrombolytic therapy among patients with acute MI.      Keywords: Acute myocardial infarction, opium, streptokinase, substance abuse.