Background and aims: To identify the pattern and causes of death and to deal with them are among the most appropriate strategies to increase human life expectancy. The pattern of death in society must be identified to cope with the causes of premature deaths. The aim of this study was to epidemiologically investigate the causes of death in people aged ۵-۱۴ years in northeastern Iran. Methods: Data on the deaths of people aged ۵-۱۴ years from Khorasan Razavi province during ۲۰۱۳- ۲۰۱۹, drawn from the Causes of Mortality Classification System of the Ministry of Health and Medical Education, were used to conduct the study. Results: Data on ۲۰۸۴ deaths were examined, of which ۸۲۴ (۴۰.۰۴%) occurred in girls. The number of deaths was ۹۷۶ (۵۳.۸۳%) and ۱۱۰۸ (۴۶.۱۷%) in the age group of ۵-۹ and ۱۰-۱۴, respectively. Traffic accidents, cancers, external causes (unexpected events), and circulatory system diseases were found as the main causes of death. Among the cancers, lymphoid leukemia, malignant brain tumors, and myeloid leukemia (۱۸%, ۱۲%, and ۷%, respectively) were the most common cancers, leading to death. In rural areas, unexpected events (۲۰%) were the leading cause of death, followed by traffic accidents and cancers (۱۹% and ۱۳%, respectively). Conclusion: Overall, the mortality rate in children aged ۵-۱۴ years due to traffic accidents and unexpected events (suffocation, burns, and the like) seems to be substantially higher in Iran compared to some developing countries and some neighboring countries such as Turkey. Given the possibility of taking preventive measures in this regard, it is necessary to develop policies to reduce the mortality rate in the age group.