Prophylactic Effect of Chloroquine and Hydroxychloroquine for COVID-۱۹ Treatment

Hydroxychloroquine (HCQ) is an anti-malaria drug; its antiviral properties are controversial, and some in vitro studies approved its antiviral effects. Many efforts have been made to prevent and treat COVID-۱۹ infections, but effective drugs for complete eradication of COVID-۱۹ have not been found yet, and all of them are supportive. We try to review some new aspects of HCQ efficacy in the prevention and treatment of COVID-۱۹ infection. Also, some data from recent clinical trials were analyzed. It has been shown that HCQ may improve some symptoms of patients, but in severe or critical stages did not have significant therapeutic effects and did not reduce the rate of mortality. In the present review article, we explained some results of recent researches, including clinical trials about the effects of HCQ in the prevention and treatment of COVID-۱۹ infection. Some studies revealed HCQ beneficial effects in outpatients, and some data showed its hazardous impacts on the heart. It was suggested that the dose of administration must be adjusted and monitored correctly; furthermore, the levels of some myocardial biomarkers such as troponin must be measured in moderate to severe COVID-۱۹ infections.

Keywords:

Hydroxychloroquine , COVID-۱۹ , OT-interval , Azithromycin , Replication