Study of injury and involvement related to lung squamous cell and adenocarcinoma caused by miRNA-۴۸۶ in children with Duchenne muscular dystrophy

Publish Year: 1400
نوع سند: مقاله کنفرانسی
زبان: English
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CHGGE01_228

تاریخ نمایه سازی: 13 مهر 1401

Abstract:

Backgrounds: Duchenne muscular dystrophy is caused by mutations in the X-linked dystrophingene with a prevalence of ۱۷.۷ per ۱۰۰,۰۰۰ boy births. Neuromuscular disorders encompass aheterogeneous group of conditions that impair the function of muscles, motor neurons, peripheralnerves and neuromuscular junctions. MicroRNAs are the well-studied members of the ncRNAsfamily. Several reports have highlighted their crucial roles in the post-transcriptionalmanipulation of several signaling pathways in different pathological conditions. miR-۴۸۶ hascentral roles in several types oncological and non-oncological conditions such as lung, liver,breast cancers, autism and..., respectively. Cancer comprises a highly heterogeneous andcomplex set of diseases associated with a variety of genetic and epigenetic aberrations. Nearly۵۰% of primary lung carcinoma patients present with distant metastasis at their first visit.Materials and Methods: In this study, Raw data associated to miRNA-۴۸۶ were extracted fromdatabases TCGA, UALCAN, Fun-Rich and GEPIA. Then it was analyzed and evaluated withbioinformatics techniques and software such as cytoNCA, MCODE and SPSS۲۶.Results: Inhibition of microRNA-۴۸۶ in Duchenne children causes LUSC and LUAD due tosimilar inhibition. According to this study, the expression level of this microRNA in LUSC andLUAD is ۷۷.۳ Read per million (Normal = ۸۹۳.۳) and ۸۱.۸ (Normal = ۶۷۶.۵), respectively. TheP(-value) of patient survival in the graph is equal to ۰.۶۵ and ۰.۵۳, respectively.Conclusion: Bioinformatics analysis shows the importance of this inhibition in children'sDuchenne. Genetic testing in Duchenne indicates early risk of lung cancer, and early preventivemeasures are taken. It will greatly help the patient, family and medical staff increases the successrate of the struggle for survival in Duchenne children.

Authors

Saber Samadiafshar

Payame Noor University, East Tehran Branch, Tehran, Iran

Ali Nik Akhtar

Payame Noor University, East Tehran Branch, Tehran, Iran

Najmeh Mohammadzade

Payame Noor University, East Tehran Branch, Tehran, Iran

Roghayeh Azizi KolusForushi

Payame Noor University, East Tehran Branch, Tehran, Iran

Nadia Garmsiri

Payame Noor University, East Tehran Branch, Tehran, Iran

Farnia Garmsiri

Payame Noor University, East Tehran Branch, Tehran, Iran