Association between catalase gene (CAT) and other involving genes in human skin ageing

Background: The elasticity of the skin and collagen fibers in the epidermis and dermis graduallydecreases which is called aging. The characteristics of aging include wrinkles, dryness andpigmentation. Generally, three groups of the genes are involved in skin aging includingantioxidant capacity, elasticity, and hydration. Defects in any of these genes cause wrinkles onthe skin. Oxygen free radicals in the skin cause oxidative stress, one of the main causes ofcollagen and elastin destruction, which ultimately leads to wrinkles and sagging skin. One of theantioxidant genes is the catalase gene, which plays an important role in converting free radicalsinto inert molecules. In this study we exhibited the association among the genes involving thehuman skin aging as well as their connections with CAT gene by creating a gene network.Materials and Methods: The genes related to hydration, antioxidant capacity and skin elasticitywere systematically collected by literature review. The gene network was created byGeneMANIA algorithm based on protein-protein interaction, genetic interaction, co-localizationand pathway.Results: We found ۵۵ genes related to skin aging. Catalase is connected to MNSOD۲,ALDH۱A۱, PCNA and CYP۱A۱ genes. Likewise, we observed JUN gene has the most biologicalconnections with the other skin aging genes.Conclusion: This study shows catalase gene in addition to antioxidant activity may also involvein skin aging and introduce JUN genes as important gene in skin aging. Our study providesinsight about the prioritization of the genes is involving in skin aging.

Keywords:

Skin aging , GeneMANIA , Catalase , gene network