Hamidreza Lotfi - Zanjan pharmaceutical biotechnology research center, Zanjan University of Medical Sciences, Zanjan, Iran
Tina Khalilzadeh - Department of Medicine, Faculty of Medicine, Laval University, Quebec, Canada
Maryam Damchi - Zanjan pharmaceutical biotechnology research center, Zanjan University of Medical Sciences, Zanjan, Iran
Maryam Hassan - Zanjan pharmaceutical biotechnology research center, Zanjan University of Medical Sciences, Zanjan, Iran

Background and Aim: Hospital-acquired infections are considered a major health concern worldwide because of the increasing morbidity and mortality rate. Hence, selecting the most efficient disinfectants in a clinic is crucial. This study evaluated the antibacterial efficacy of seven mostly used disinfectants against clinically isolated Escherichia coli. Materials and Methods: For this purpose, minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) of Aniosyme DD۱ ۰.۵%, Steranios ۲%, Aniospray ۲۹ and Surfanios ۰.۵% at Hazrat Valiasr hospital and PROSEPT® Floor ۰.۷۵%, PROSEPT® Instru ۰.۰۵% and PROSEPT® Med used at Ayatollah Mousavi hospital were determined both in the presence and absence of bovine serum albumin (BSA) using microbroth dilution assay. Results: The results indicate that PROSEPT® Med had the lowest MIC and MBC values, followed by Aniospray ۲۹ and PROSEPT® Instro, and the presence of BSA reduced antibacterial activities of disinfectants. Conclusion: The disinfectants applied at Ayatollah Mousavi hospital generally had higher antibacterial activities. Due to the importance of nosocomial pathogens at healthcare centers, selecting the most potent, fast-acting, and efficient disinfectants to prevent hospital-acquired infections is essential.

Disinfectants, Escherichia coli, Hospital-acquired infections, Minimum bactericidal concentrations, Minimum inhibitory concentrations, ضد عفونی کننده ها, اشریشیا کلی, عفونت های بیمارستانی, حداقل غلظت باکتری کش, حداقل غلظت های بازدارنده