Appraisal of the Role of Apelin and Visfatin in Ischemic Heart Patients

The disease of the ischemic heart is still a severe burden on individuals and healthcare resources all over the world. Flow-limiting obstruction in large–medium-sized coronary arteries is usually linked with atherosclerotic plaque. Aim of the study: To assess visfatin, apelin Vit-D۳, and lipid profile concentration in thrombus and hypertension patients. The current study involved ۳۵ ischemic heart disease solely patients (group ۱), ۳۳ with ischemic heart disease plus hypertension patients (group۲), and ۳۵ as healthy control (group۳). Apelin, visfatin, troponin, Vit-D۳, and lipid profile levels were evaluated. In the cases of thrombus with hypertension and thrombus only patients, blood apelin, visfatin, triglyceride, total cholesterol, LDL, and VLDL levels were considerably higher, and blood Vit-D۳ and HDL levels were considerably lower than in the healthy controls group. The findings of this study suggest that serum apelin, visfatin, troponin, and lipid profile may not only do pathogenicity a part in the occurrence of the disease but also play a role in the severity of IHD. More than apelin, the circulating amount of visfatin is a particular indicator for IHD.

Keywords:

Ischemic heart disease , Visfatin , apelin , lipid profile , Troponin