Synthesis and Characterization of Bulky and Nano Complexes of Telmisartan with Some Heavy Metal Ions (Ru۳+ and Au۳+) and Their Anticancer Activity

New complexes of Telmisartan (Telm.) were prepared in this research, where telmisartan used as a chelating agent with trivalent heavy metal ions of ruthenium and gold. The complexes were prepared by conventional method in bulky size, and characterized in solid state by using different measurements included: the spectroscopic analysis acts by UV-Vis and FT-IR, metal composition percent and other elements (C, H, and N) analysis, physical measurements (color, melting points, magnetic susceptibility, and electrical conductivity). The results obtained from these measurements show the coordination sites for the ligand with the metal ions as bi-dentate through two oxygen atoms of telmisartan and the complexation process was succeeded through the reaction of (۲ ligand:۱ metal ion). Analytical and spectroscopy studies disclosed octahedral structure for Ru(III) complex and square planner structure of Au(III) complex, also show the electrical nature of Au(III) complex, while the opposite for Ru(III) complex. The bulk complexes were converted into nano scale by using an ultrasonic probe device with a period of about ۱.۵ hours with rolling every ۲۰ minutes, and then identified by (AFM, XRD, and FTIR) analysis. All prepared complexes were applied as antitumor against MDA-MB-۲۳۱ cell line in vitro by the MTT method by using different six concentrations (۱۲.۵, ۲۵, ۵۰, ۱۰۰, ۲۰۰, and ۴۰۰ µ/mL) for ۲۴ hours. In general, the results showed that all complexes have the greatest inhibition rate at a high concentration, but specifically the overall order of inhibition for all compounds is Nano Au-Telm > Nano Ru-Telm > Au-Telm > Ru-Telm > Telm.

Keywords:

Antitumor Agents , Heavy metal , Nanoscale , Telmisartan , Ultrasonication