جهانگیر حقانی - Endodontology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
فاطمه حقانی - Department of Physiology and Pharmacology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
امیرحسین سلیمانی - Physiology Department, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
مهدی عباس نژاد - Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
مجتبی خدامی - Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran
راضیه کوشکی - Department of biology, Faculty of Science, Lorestan University, Khorramabad, Iran.
مریم رئوف - epartment of Orofacial Pain and Dysfunction, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, Netherlands.

This study considered the therapeutic efficacy of three different Artemisia species extracts on capsaicin-induced dental pulp pain and pain-associated changes in feeding behaviors in adult male Wistar rats. The animals were alienated into five groups (n=۶), comprising: sham, capsaicin, and capsaicin groups pre-treated with hydroalcoholic extracts of A. sieberi, A.persica, and A.biennis. Pulpitis was evoked by intradental administration of capsaicin (۱۰۰ µg). The plant extracts (۲۰۰ mg/kg/ i.p.) were administered ۱۰ min before capsaicin. Pain scores were recorded for forty min. Afterward, feeding behavior was evaluated within ۶ hours. All extracts could suppress capsaicin-related dental pulp pain. Furthermore, capsaicin decreased the number of visits to the food and water ports of the feeding behavior evaluation device that led to a reduced amount and duration of meals consumed. These harmful effects of capsaicin on meal duration, and frequency were attenuated by A.persica. Moreover, capsaicin inhibitory effect on food intake and water consumption was suppressed by all the extracts. Taken together, the present study showed that Artemisia species extracts are useful in supressing capsaicin-induced pulpal pain and pain-induced feeding abnormalities.

Pulpitis, Capsaicin, food intake, Artemisia, Rats