Introduction: Distance rehabilitation includes rehabilitation services, support and information provided through information technology and remote communication. Due to the crisis of the Covid-۱۹ pandemic, adequate patient care has become a global challenge. Therefore, in this dynamic clinical situation, a systematic review in the field of alternative care solutions is considered a necessity as a way to connect evidence, practice and guide clinical care. Therefore, the aim of this study was a systematic review on the effect of telerehabilitation in improving performance and quality of life in patients with musculoskeletal problems. Methods: A systematic review of randomized controlled clinical trial studies without time limit was explored by searching keywords in the title, abstract and keywords of the studies in the reliable scientific databases Embase, Web of Science, Scopus, PubMed on October ۲۰, ۲۰۲۱. The quality of the studies was evaluated using the JBI checklist; that the studies with a score above ۷ were included in the analysis. This study was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Clinical or randomized controlled trial studies that used telerehabilitation or telephysiotherapy methods to improve physical performance in patients with musculoskeletal problems and the full text of the articles were available in English were included in this study.Results: First, ۲۱۴۲ documents were extracted by searching in scientific databases. ۸۳ related articles were selected for full text screening and finally ۶ studies that met the inclusion criteria were included in the review. The population of people in the studies included ۲۵۱۰ people. The duration of treatment follow-up varied from ۶ weeks to ۶ months. Distance rehabilitation approaches included support application (۳ cases), phone call (۲ cases) and video call (۱ case). In two studies, there was no significant improvement in functional status (intervention with support application) and in two other studies, improvement in quality of life (intervention with telephone calls) including faster access to treatment and promotion of physical activity of patients was observed. Other studies reported similar improvement in control and intervention groups. In two of the studies, the participants in the intervention group expressed their interest and satisfaction in using telerehabilitation. So that this approach had increased their expectation of treatment and improved self-management in them.Conclusion: The results of our systematic review showed that telerehabilitation in patients with musculoskeletal problems can be at least as effective as face-to-face rehabilitation services. Due to the increasing interest and satisfaction of patients to receive treatment in these types of approaches, telerehabilitation is a promising alternative treatment for these patients. Paying attention to the better effect of telerehabilitation approaches based on patient self-management programs promises to promote physical activities and adherence to the recovery path among people with musculoskeletal diseases, so in future studies focusing on a combination of application-based approaches with Telephone calls are recommended in order to maximize the effect of self-management in these patients.