Interactive Effects of Endurance Swimming and Curcumin Supplementation on Serum Levels of Liver Alkaline Phosphatase in Male Rats Following Ethanol Abuse

In this study, ۴۸ male wistar rats approximately ۱۲ weeks old with  ۲۴۰ ±۱۰g weight are selected.(۱st) ۸ rats were randomly separated as control group and ۴۰ rats in ۵ equal group were gavaged with ethanol (۵-۷ g/kg weight of body) every ۸ hours for ۴ days. Six days after the final binge, (۲nd) the rats were randomly divided into groups of alcohol with any intervention, exercise, curcumin, sham and exercise + curcumin. Endurance swimming training program was conducted for two weeks, daily and ۲۰-۶۰ min, equally in groups with exercise. There was daily intra-peritoneal injection of curcumin (۵۰mg/kg weight of body), equally in groups with curcumin. Rats in sham group were injected with curcumin’s solvent (dimethyl sulfoxide). The data were analyzed by ANOVA and Tukey's post hoc test at the significant level of p< ۰.۰۵. Plasma level of ALP enzyme (p=۰.۰۰۰۱) significantly increased in the alcohol group compared to the control group. Also the result show that the was significantly decreased in training + curcumin group in comparison with curcuminand training groups. According the finding,alcohol abuse significantly increase Plasma level of  ALP enzyme. It seems that Short-term exercise with curcumin, caninhibit enzymthat enhanced by alcohol abuse.

Keywords:

Endurance swimming , Curcumin supplementation , Alkaline phosphatase , Ethanol abuse