Due to the increase in the rate of addiction among women; and the importance of the role of parenting and managing for women at home, the importance of health is felt in this stratum by the community and one of the most affecting factors on health is regular exercise. This study aimed to investigate the effectiveness of the ۸-weeks combined exercise with methadone on liver enzymes (including: ALT, AST, ALP) in withdrawal addiction females. This semi-experimental study was done at Zahedan addiction Camp on ۴۳ available addicted women divided two groups of methadone (N: ۲۰) and methadone with exercise (N: ۲۳), randomly by the same variables such as age, type and duration of drug withdrawal and body mass index. Levels of liver enzymes were assessed by blood sampling before and after ۸-weeks. To compares the means between two groups on the same continuous, independent t-test and to compare two means were from same group (pre test vs. post test) paired t-test via SPSS software version ۲۴ were used. Statistical significant level P was taken to be less than ۰.۰۵ (P<۰.۰۵). Results showed that the levels of liver enzymes (ALT, AST, ALP) in both groups decreased; which one except ALP in methadone with combined exercise group (T=-۱.۷۰۱, P=۰.۱۱۷) all of them were significant (P<۰.۰۵). Also, independent t-test showed no significant difference between post-test’s levels of AST, ALT, ALP enzymes between methods (P>۰.۰۵). This was a good pilot study upon which it might want to use a more robust study by the bigger sample size to detect more and various findings and from the new technological aspects it suggests that combination exercise (aerobic + strength training) could be a new useful way to use with consuming methadone at withdrawal addiction females probably, too.  

ALT, AST, ALP, Combined exercise, Withdrawal addiction females