Humoral Immune Durability of Anti-SARS-CoV-۲ Antibodies in Southern Iran: A Population-Based Survey Study

Publish Year: 1400
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_IEJM-10-4_003

تاریخ نمایه سازی: 3 آبان 1401

Abstract:

Background: To promote mitigation strategies and public health response, this study aimed to evaluate the population-based seroprevalence of anti-severe acute respiratory syndrome coronavirus ۲ (SARS-CoV-۲) antibodies in Hormozgan province.Materials and Methods: The study was conducted within ۱۰ districts of Hormozgan province with ۱۳۲۵ participants for three months by considering three-month successive follow-ups to evaluate the durability of humoral immunity. The participants completed the questionnaire, and blood samples were taken followed by immunoassay SARS-CoV-۲ ELISA testing.Results: In general, ۷۱۷ (۵۴.۱%) males and ۵۹۶ (۴۵.۹%) females participated in this study. In phase one, ۱۴۷ (۱۱.۱%) and ۱۸۲ (۱۴.۷%) tested positive for immunoglobulin M (IgM) and IgG, respectively. Upon three months, ۱۳.۸% and ۱۷.۸% tested positive for IgG and at least for one of the antibodies. Based on the results, ۶۰۶ (۴۵.۷%) cases reported no symptoms while ۶۷۳ (۵۰.۸%) of them reflected at least one. Among ۷۹۸ (۶۰.۲%) participants, the most common symptoms were headache (n = ۲۴۴, ۱۸.۴%), sore throat (n = ۱۸۶, ۱۴.۰%), weakness (n = ۱۵۰, ۱۱.۳%), muscular pain (n = ۱۳۹, ۱۰.۵%), and sputum cough (n = ۱۳۴, ۱۰.۱%). The odds of the antibodies in females was ۱.۳۷ (۹۵% CI: ۱.۰۳, ۱.۸۲, P = ۰.۰۳). In phase ۲, ۴۳ (۵.۳%) participants persisted positive for IgG while ۵۵۹ (۷۳%) tested negative for IgG. Finally, ۲۰% of the suffered participants tested positive for IgG until nine months.Conclusion: Although IgG antibodies decreased in the first six months, their titers persisted stable for nine months. It seems our population has not reached a desirable level of protection. It is stressed that mass vaccination is needed to prevent future epidemic waves.

Authors

Hossein Farshidi

نویسنده اول

Mehdi Hassaniazad

نویسنده دوم

Mahmood Hosseinpoor

نویسنده سوم

Abdollah Gharibzadeh

نویسنده چهارم

Amin Reza Nikpoor

نویسنده پنجم

Shokrollah Mohseni

نویسنده ششم