Evaluation of the effect of crocin on prevention of atrial fibrillation after coronary artery bypass grafting or heart valve replacement: A double-blind, randomized, placebo-controlled trial

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:

JR_AJP-12-6_004

تاریخ نمایه سازی: 7 آبان 1401

Abstract:

Objective: The aim of this study was to evaluate the effect of crocin on the prevention of atrial fibrillation after coronary artery bypass grafting (CABG) and heart valve replacement.Materials and Methods: ۱۰۰ patients who were scheduled for CABG or heart valve replacement surgeries were randomly assigned into two groups of treatment and placebo. In the treatment group, patients received crocin tablets from three days prior to surgery and on the first three postoperative days (for a total of six days). During the first three days after surgery, postoperative atrial fibrillation (POAF) was assessed by electrocardiogram monitoring. Prooxidant–antioxidant balance (PAB) and c-reactive protein (CRP) levels were also assessed.Results: POAF developed in ۷ patients in the treatment group versus ۱۸ patients in the control (p=۰.۰۲). PAB levels were significantly lower in the crocin group (p<۰.۰۰۱), while differences in CRP levels were insignificant (p=۰.۳۹).Conclusion: It seems that prophylactic use of crocin is effective in reducing the incidence of POAF in patients undergoing heart surgeries.

Keywords:

Atrial fibrillation , Coronary artery bypass graft , Heart valve replacement , Crocin

Authors

Seyyed Hamed Hashemi Shahri

Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Ghasem Soltani

Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Abbasi Teshnizi

Cardiac Surgeon, Department of Cardiac Surgery, Mashhad University of Medical Sciences, Mashhad, Iran

Aliasghar Moeinipour

Cardiac Surgeon, Department of Cardiac Surgery, Mashhad University of Medical Sciences, Mashhad, Iran

Mohammad Tayyebi

Vascular and Endovascular Surgery Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Reza Javidi Dasht Bayaz

Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Farshad Abedi

Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

Vahid Ghavami

Department of Biostatistics, Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Shahram Amini

Department of Anesthesia, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

Amir Hooshang Mohammadpour

Department of Clinical pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran