Mohaya Farzin - Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran- Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
Parastoo Jafarzade - Department of Physiology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Niloofar Faraji - Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
Seyedeh Maral Mousavi - Razi Clinical Research Development Unit, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran
Mostafa Yousefi - Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran

Ghrelin does an important role in neurological functions such as memory, learning, and cognition as well. There is some evidence that ghrelin can improve memory. This study aimed to evaluate the effects of ghrelin on rat memory. A systematic search was conducted to identify papers published by Iranian authors in the Web of Science, PubMed, Scopus, Embase, and Google Scholar electronic databases from January ۲۰۱۰ to December ۲۰۱۹ with the PRISMA statement. Totally, ۵۴۷ animals were listed in our systematic review. All of the animals were male Wistar rats with a mean weight of ۲۵۰±۲۸۰ g. The Morris Water Behavior behavioral test and the passive avoidance task were performed to evaluate memory. Truly, injection of ghrelin appears to enhance the compactness of the synapse dendritic spines in the hypothalamus. These findings indicate that ghrelin has a prospective role to recover learning and memory ability in animal models, suggesting it as a candidate therapy for memory.

Ghrelin, Memory, Depression, Memory disorders