Autologous Plasma Rich Platelet versus Low Molecular Weight Hyaluronic Acid in knee osteoarthritis: A Non-Placebo Randomized Controlled Trial
Publish place: Social Determinants of Health، Vol: 6، Issue: 1
Publish Year: 1399
نوع سند: مقاله ژورنالی
زبان: English
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شناسه ملی سند علمی:
JR_JSDI-6-1_009
تاریخ نمایه سازی: 9 آبان 1401
Abstract:
Background: This study aimed to compare the effect of autologous plasma rich platelet (PRP) versus Low molecular weight Hyaluronic acid (HA) on pain, function, and stiffness in knee osteoarthritis during six months follow-up.Methods: Through a non-placebo blocked randomized controlled trial with parallel design on ۷۷ patients with knee osteoarthritis; ۵۰ in the intervention group, treated by PRP; ۲۷ in the control group, treated by HA. They received three injections and assessed before, after two and six months. Pain, stiffness and function were assessed using WOMAC and VAS. Descriptive statistics, chi-square, and ANOVA were used when appropriate.Results: Pain reduced in both groups compared to their respective baseline (P<۰.۰۰۱); the reduction rates were similar in both groups (P>۰.۰۵). WOMAC and VAS scores were different between before injection and both two and six months follow-ups in both groups (P<۰.۰۰۱); although the increase of VAS score between two and six months follow-ups was more considerable in PRP but not statistically significant (P=۰.۰۸). Considering Kellgren-Lawrence classification of knee osteoarthritis, WOMAC scores were different in patients with grade ۲ and ۳ in both groups (P<۰.۰۰۱); but VAS scores were different with grade ۳ only in the PRP group (P=۰.۰۰۹). Conclusion: There was no difference between PRP and HA in reducing symptoms of knee osteoarthritis compared to their baseline but the sustainability of the effect may be more with HA.
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Authors
Zahra HajihHashemi
Department of Rheumatology, Imam Hossein Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad-Mehdi Emam
Department of Rheumatology, Loghman Hakim Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Mohammad-Reza Sohrabi
Department of Community Medicine, Social Determinants of Health Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran