Mehdi Rahab - Effects of Dexmedetomidine on Clinical Outcomes and RenalFunction after CABG
Evaz Heydarpour - Rajaie Cardiovascular, Medical and Research Center, Tehran, Iran
Ziae Totonchi - Rajaie Cardiovascular, Medical and Research Center, Tehran, Iran
Naser Karchoueian - Department of Cardiovascular Surgery, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Sam Zeraatiannejad Davani - Department of General Surgery, School of Medicine, Hazrat-e Rasool General Hospital, Iran University ofMedical Sciences, Tehran, Iran
Mehrdad Mesbah Kiaei - Department of Anesthesiology, School of Medicine, Hasheminejad Kidney Center, Iran University of MedicalSciences, Tehran, Iran

Background: This study was carried out to determine the effects ofdexmedetomidine on clinical outcomes and renal function after coronary arterybypass grafting (CABG) to address the increased rate of CABG? and theimportance of modification in stress responses and control of adverse effects onrenal function and with the aim of cost reduction.Materials and Methods: This double-blind randomized clinical trial wascarried out with the participation of ۱۲۹ subjects under elective CABG in RajaeiHeart Center, Tehran, Iran in ۲۰۱۷. Patients were randomly assigned to fourgroups with simple randomization including one placebo (normal salineinfusion) group and three dexmedetomidine groups; ۰.۵ μg/kg/h on CPB, ۰.۵μg/kg/h in ۲۴ hours, and ۰.۷۵ μg/kg/h in ۲۴ hours. The blood pressure, bloodurea nitrogen (BUN), serum creatinine, transfused blood volume, urine volume,and hemofiltration on pump and lactate were assessed at different time intervals.Results: Results showed more stability especially in central venous pressure(CVP) (p=۰.۰۰۱) and systolic blood pressure (p=۰.۰۰۶) in the groupsreceiving dexmedetomidine ۰.۷۵ μg/kg/h per ۲۴ hours. But diastolic bloodpressure and heart rate were the same across the groups (p>۰.۰۵). All othervariables including hepatic and renal function tests were the same across thegroups (P>۰.۰۵).Conclusion: Overall, according to the obtained results in the current study, itmay be concluded that dexmedetomidine would have some promising effectson hemodynamic stability but there are no obvious renoprotective effects forthis medication.

Coronary Artery Bypass Graft, Dexmedetomidine, Renal Function