Milad Zandi - Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran- Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
Saber Soltani - Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran- Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran, Iran
Samira Sanami - Department of Medical Biotechnology, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran
Azadeh Rasooli - Department of Biochemistry, Faculty of Sciences, Payame Noor University, Tehran, Iran- Virology Department, Pasteur Institute of Iran, Tehran, Iran

The severe acute respiratory syndrome coronavirus ۲ spike (S) glycoprotein facilitates receptor binding to initiate cell entry that is the critical initial step in the infection cycle. Due to S glycoprotein's pivotal role, in this review, we pointed to show potential functional and structural consequences of S glycoprotein and its variants, which has been related to increased viral load in humans with SARS-CoV-۲ infection.

Spike glycoprotein; Mutation, Macromolecule, COVID-۱۹, SARS-CoV-۲