Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery

Publish Year: 1401
نوع سند: مقاله ژورنالی
زبان: English
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JR_TIPS-8-3_003

تاریخ نمایه سازی: 24 آبان 1401

Abstract:

Gold nanoparticles (AuNPs) exhibit a variety of attractive physical, chemical, optical, thermal, and biological properties, making them potential candidates for non-toxic drug and gene delivery carriers. The surface modifications of AuNPs vastly enhance their circulation, minimize aggregation rates, and increase their targeting capability. In this investigation, cetyltrimethylammonium (CTAB) coated AuNPs were prepared and characterized for potential application in gene delivery. This surface modification can lead to the improvement of dispersibility and stability in aqueous solution, and surface charge density. In this study, CTAB coated AuNPs were complexed with plasmid DNA (pUMVC۳-hIL-۱۲) via electrostatic interaction and resulted in the formation of nano-sized CTAB-AuNP/plasmid DNA complexes with the size of ۸۴.۷±۹.۸ nm.  The zeta potential of these complexes was surface +۴ mV at carrier: plasmid (C/P) ratio of ۱۰. These complexes could condense the pDNA at C/P ratios of ۸ and ۱۰ and protect it against nuclease enzyme at C/P ratios of ۴, ۸, and ۱۰. This study suggests that CTAB coated gold nanoparticles can be tested for potential applications in nucleic acid delivery.  Keywords: Gene delivery, gold nanoparticles, cetyl trimethyl ammonium bromide, pUMVC۳-hIL-۱۲. Please cite this article as: Sepideh Pouya, Maryam Kazemi, Setareh Pouya, Ali Dehshahri, Zahra Sobhani. Evaluation of CTAB coated gold nanoparticles as a potential carrier for gene delivery. Trends in Pharmaceutical Sciences. ۲۰۲۲;۸(۳):۱۴۷-۱۵۴. doi: ۱۰.۳۰۴۷۶/TIPS.۲۰۲۲.۹۵۵۰۵.۱۱۴۶

Keywords:

Keywords: Gene delivery , Gold nanoparticles , cetyl trimethyl ammonium bromide , pUMVC۳-hIL-۱۲

Authors

Sepideh Pouya

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Maryam Kazemi

Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran.

Setareh Pouya

Department of Optometry, Faculty of Rehabilitation, Iran University of Medical Sciences, Iran.

Ali Dehshahri

Department of Pharmaceutical Biotechnology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

Zahra Sobhani

Drug and Food Control Department, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.

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