Antioxidant Activity of New Synthesized Pyrazole and ۲-Oxo-۳H-Pyrimidine Derivatives Containing Imidazo(۱,۲-a) Pyridine
عنوان مقاله: Antioxidant Activity of New Synthesized Pyrazole and ۲-Oxo-۳H-Pyrimidine Derivatives Containing Imidazo(۱,۲-a) Pyridine
شناسه ملی مقاله: JR_JMCH-6-5_021
منتشر شده در در سال 1402
شناسه ملی مقاله: JR_JMCH-6-5_021
منتشر شده در در سال 1402
مشخصات نویسندگان مقاله:
Doaa Hashim Al-Abboodi - Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
Naeemah Jabber Al-Lami - Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
خلاصه مقاله:
Doaa Hashim Al-Abboodi - Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
Naeemah Jabber Al-Lami - Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq
In this research, chalcone, cyclic pyrazole, and oxo-pyrimidine compounds were prepared from the reaction of start material ۲-amino pyridine with bromo phenacyl bromide constituted in the first step ۲(۴-bromo phenyl) imidazole (۱,۲-a) pyridine compound (۱). In the following step, compound (۱) was treated with ۴-amino acetophenone in the presence formaldehyde giving Mannich base (۲). In the third step compound (۳) condensed with aromatic aldehydes under cross aldol reaction to give the new chalcones from ۳A to ۳E. In the last step, chalcone derivatives were cyclized by hydrazine hydrate and urea compounds for giving pyrazole and oxo-pyrimidine rings (۴A-۴E), (۵A-۵E), respectively. All the prepared compounds were subjected to FT-IR, ۱H-NMR, and ۱۳C-NMR spectroscopies, and also, they were evaluated as antioxidant.
کلمات کلیدی: Imidazo (۱, ۲- a) pyridine Chalcone Cyclic ring Pyrazole ring oxo-pyrimidine rings antioxtant
صفحه اختصاصی مقاله و دریافت فایل کامل: https://civilica.com/doc/1555222/