Synthesis, Structure, and in vitro Cytotoxic Activity of Two Organotin Complexes of ۲-[(۲, ۳-Dimethylphenyl) Amino] Benzoic Acid

Organotin carboxylates have gotten a lot of attention in recent years because of their structural intrigue and several uses. The production and characterization of organotin carboxylates, as well as their action against cancers, fungi, bacteria, and other microbes have been described by a number of researchers. Some di- and triorganotin carboxylates have been found to have the potential as anticancer drugs. The amount and kind of organic groups bound to the tin core and carboxylate ligand appear to have a significant impact on their anticancer efficacy. Two new organotin complexes of di and triorganotin carboxylate were successfully synthesized by refluxing reaction of ۲-[(۲,۳-dimethylphenyl) amino] benzoic acid (ligand) with tri phenyl tin chloride and dimethyl tin dichloride salts to give the corresponding substituted tin complexes with high yields. The chemical structures of the complexes were confirmed by different techniques included elemental analysis, proton, carbon and Sn۱۱۹-NMR, and FT-IR-spectra. The activity of each complex has been examined against the target cell line A-۱۷۲ compared with the ligand alone. It was found that the complex ۱ and ۲ have higher cellular cytotoxicity than ligand.

Keywords:

Antitumor , Cytotoxic activity , Ligand , triorganotin carboxylate