Samir A. Malik - AL-Mustaqbal University College, Department of Pharmacy, Babylon, Iraq
Karima F. Ali - ۲College of Pharmacy, Al-Mustansiriya University, Baghdad, Iraq
Ashour H. Dawood - Al-Esraa University College, Baghdad, Iraq

This study aimed to synthesize new ferulic acid derivatives through preparing new compounds containing a heterocyclic group that are expected to be biologically effective for diagnosis and studying pharmacological efficacy through these groups. These new compounds are primarily screened (in vitro) for their cytotoxic activity against human lung (A۵۴۹) and breast (MCF-۷) cancer cell line, ۱H-NMR, ۱۳C-NMR spectroscopy, and FT-IR spectra. Pharm kinetic study by Swiss ADME suite was examined, utilizing molecular docking software (GOLD suite v. ۵.۷.۱), the selectivity for EGFR and ER-receptors, cytotoxicity evaluation tested compounds in vitro IC۵۰ showed compounds (۴a and ۴b) are more active anticancer (۴۷۸.۳۲ and ۵۶۱.۱۲ µg/mL), respectively than reference erlotinib (۵۸۲.۷۳), while the compounds ۴a, ۴b, and ۴c, respectively is the more active anticancer than standard tamoxifen (۳۹۲.۳ µg/mL).

ferulic acid, heterocyclic group, Molecular docking, ADME study