Ghazal Ghajari - Department of Cell and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Arijit Chakraborty - Department of Sports Physiology and Nutrition, National Sports University (A Central University), Imphal, Manipur, India
Seyed Akbar Moosavi - School of Paramedical Sciences, Iran University of Medical Sciences, Tehran, Iran
Mahnaz Saremi - Reference health laboratory, Ministry of health and medical education

The goal of precision medicine (PM) is to provide each patient with the treatment and therapy with the optimum  results without significant adverse side effects. PM play an  essential role in patient care as well as therapy because it tailores the medicine on the individual basis, thus decreasing  side effect associated with the drug administration and expediting the treatment as well . Antidepressant drug sertraline (SRT) is currently  prescribed to treat mental disorders. This study aimed to determine how much Ganoderma lucidum protects against SRT-induced testicular damage in mice. Mice were given SRT (at a dosage of ۳۰ mg/kg) orally for ۳۵ consecutive days. For ۳۵ days straight, rats receiving SRT were also given G. lucidum extract (at a dosage of ۳۰۰ mg/kg). SRT therapy caused immediate testicular injury, as evidenced by the significant degeneration and necrosis of the germ cell lining and an increase in sperm malondialdehyde (MDA) levels. Additionally, evaluation of sperm parameters using computer-assisted sperm analysis (CASA) results demonstrated a substantially lower volume, movement, and survival of sperm in the SRT-treated group (p < ۰.۰۰۱). Administering G. lucidum extracts to animals that had received SRT may have reduced their histological changes. G. lucidum significantly decreased spermatozoa’s lipid peroxidation, and its antioxidant defenses were strengthened. Finally, G. lucidum protects mice›s testicles from harm brought on by SRT, most likely due to its capacity to inhibit reactive oxygen species.

Oxidative stress, Reproductive toxicity, Sertraline, Ganoderma lucidum