Najneh Karimi - Institute of Zoology, Chinese Academy of Sciences, State Key Laboratory of Stem Cell and Reproductive Biology, Beijing China

Overweight and obesity are defined as abnormal or excessive fat accumulation that presents a risk to health. In ۲۰۰۸, the World Health Organization (WHO) estimated that ۱.۴ billion adults worldwide were overweight; of these, ۲۰۰ million men and ۳۰۰ million women were obese. It is predicted that more than one billion people in the world will be obese by ۲۰۳۰. Obesity is a major cause for the development of debilitating conditions such as type ۲ diabetes, cardiovascular disease, hypertension, and non-alcoholic steatohepatitis, all of which reduce life quality as well as lifespan. Obesity affects more people worldwide than any other debilitating disease. Wild-type lean C۵۷BL/۶J mice were placed on ۶۰kcal% High Fat Diet (HFD;Research Diets) at the age of three weeks soon after weaning, and maintained on the same diet for۱۶-۲۰ weeks before the experiments. Injection of DMSO (as a control group) and Firategrast (۴mg/kg) Intraperitoneally every day. Firategrast blocks reduction of energy expenditure, and leads to up to weight loss in High Fat diet induced obese (DIO) mice. Overall, Firategrast may be used as a new tool in weight management due to its ability to reduce performance indicators.

Overweight, Energy expenditure, Food Intake, Body Weight.