Investigating the comparative effect of concentrated extract and aqueous extract of (Opuntia SPP) fruit on type ۱ diabetes in rats

Review:Type ۱ diabetes is one of the most common underlying diseases among the human society today. With the progress of science, the use of nature's potential as one of the cases and solutions of treatment is becoming more colorful every day. Opuntia plant is a native plant of North America. And it is very resistant to heat. The fruit of this plant is a fruit called prickly pear. Today, in some parts of Iran, this type of plant is cultivated in a limited way.Materials and methods:In this study, which was conducted in the research laboratory of Badian Tabazma company in Dehlran city, ۳۰ male rats were used, which were injected IP with streptozocin (۷۵ ml/kg) to induce type ۱ diabetes and then From the measurement of BS (blood sugar) and its confirmation, the treatment with the desired substance was started for ۵ days. After collecting Prickly pear, extraction was done by maceration method, and one extract was pure and one extract was concentrated by rotary evaporator, and the extracts were gavage and distilled water for the control group for one month on the animals. was used.findings :After the development of diabetes and the use of the extracts, the group receiving the concentrated extract showed signs of a decrease in BS in their blood at the beginning of the ۴th day, although the blood sugar measured in the group receiving the aqueous extract also showed signs of diabetes reduction on the ۱۱th day. But there was a significant difference with the first group, and on the ۱۴th day, it can be said that the FBS of the group receiving the concentrated extract had decreased to an acceptable level, but there was a significant difference with the receiving group.Conclusion:According to this research, it can be considered that prickly pear can be one of the helpers in controlling blood sugar in people with type ۱ diabetes and its products can also be used as a blood sugar reducer.

Keywords:

type ۱ diabetes , cactus fruit , prickly pear , Opuntia